Jrnl of Neuroscience 2/9/11
Saturday, April 23, 2011
NIH researchers have found a pathway that regulates production of kinase-C. By modifying p300, researchers can possibly reduce the expression of kinase-C and the associated destructive effects on dopamine-producing cells. Next.... to find the chemicals to control the mechanism.....
Monday, April 11, 2011
Hearing loss is linked to dementia in individuals older than 60. Hearing loss may be causally related to dementia, maybe through exhaustion of cognitive reserve, social isolation, environmental differentiation, or a combo of these.
One wonders if the use of digital hearing aids, cochlear implants, or other rehabilitative strategies to treat hearing loss would result in a decreased risk for dementing illness.
Arch Neurol. 2011 ; 68(2):207-213
Sunday, April 10, 2011
Serene Branson while reporting live at the Grammy Awards suddenly began having difficulty speaking.She was hospitalized at UCLA Medical Center in LA and after a neurologic workup was diagnosed with migraine.She had no prior history of migraine and recovered completely.
Another TIA mimic may be related to seizures. For example, following a seizure , some patients may experience sided paralysis called Todd's paralysis which resolves without sequelae.
To aid the physician in diagnosis the ABCD2 algorithm score based on age, blood pressure, clinical features, a history of diabetes and TIA duration can predict stroke risk.
A prior history of unexplained transient neurologic attacks, the presence of non- specific symptoms, and gradual symptom onset can help differentiate between TIA and TIA mimics such as migraine.
With migraine, symptoms occur over minutes. In TIA's over seconds.
With TIA mimics, patients often report other non-focal symptoms such as lightheadedness, GI complaints and tightness of the chest.
In 2010, the American Stroke Association revised diagnostic criteria for TIA.
All of the aforementioned can assist the physician in making a correct diagnosis and most importantly identify those at risk for stroke.
AHA/ASA Guidelines for the prevention of stroke in patients with TIA's ( Stroke 2011; 42: 227-276)