Monday, May 30, 2011

Safinamide for Parkinson's Dyskinesia

Safinamide has been shown in animal models to inhibit glutamate release. Levadopa treatment is believed to cause glutamate release. Studies in primates show that levadopa-induced dyskinesia can be blocked by safinamide.
In a study of 214 patients with PD and dyskinesia, those that received 100 mg/d of safinamide experienced a reduction of 24 % compared to placebo.
AAN 2011 annual meeting

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