Elective or spontaneous abortion seems to be associated with radiologic and clinical inflammatory relapse in women with Multiple Sclerosis according to data from eight Italian MS centers.
Elective abortion was associated with the higher relapse rate at 70% compared to 47% for miscarriages.
Higher stress was suggested as a factor in the elective abortion group.
The hypothesis for these findings suggests up-regulation of pro-inflammatory mechanisms usually occurring in the first trimester.
Women should be informed of the risks for disease reactivation.
J Neurol Neurosg Psychiatry 2018;Epub 2018 Jul 3