PPI's (omeprazole, pantoprazole, lansoprazole, esomeprazole) have been found to be associated with vascular dysfunction including kidney disease, heart attacks and dementia. A recent American Heart Association presentation indicates that a review of records of 244,679 Danish patients with nearly a six year follow up revealed a 21% overall increased risk of ischemic stroke in those taking PPI's. The greatest risk was found with pantoprazole (94%).
A similar risk was not found in those that took H2 blockers (famotidine, ranitidine).
AHA Meeting Report Presentation: 391-Session: EP.AOS.765