Researchers studying biomarkers in the spinal fluid of 1,798 patients found a statistically significant interaction between APOE-e4 and sex on CSF total tau and phosphorylated tau.
Meaning there is a stronger association between APOE-e4 and spinal fluid tau levels among women than among men.
Alzheimer's disease is associated with increased total tau and phosphorylated tau in spinal fluid.
Therefore, having one copy of the genetic mutation APOE-e4 is associated with 3 times the risk of developing Alzheimer's in women compared to the general population whereas one copy in men have a risk similar to the general population. Two copies of APOE-e4 is associated with 15 times the risk of developing AD.
JAMA Neurol. 2018 May 7