Safinamide has been shown in animal models to inhibit glutamate release. Levadopa treatment is believed to cause glutamate release. Studies in primates show that levadopa-induced dyskinesia can be blocked by safinamide.
In a study of 214 patients with PD and dyskinesia, those that received 100 mg/d of safinamide experienced a reduction of 24 % compared to placebo.
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