Sunday, June 17, 2012

Potential Treatment for Alzheimer's Disease :Bexarotene

I have been in email communication with the lead investigator Gary Landreth,Ph.D. of Case Western Reserve University ( my father's alma mater ) in my home town of Cleveland, OH as I am very excited about his preliminary findings in using bexarotene ( Targretin ) in mouse models of Alzheimer's disease. This drug has been FDA approved for the treatment of cutaneous T-cell lymphoma, has been in use in humans in this capacity for 10 years and has a favorable safety profile.
In this experiment led by Paige E. Cramer, after a 14 day treatment period, there was a sustained 30% reduction in soluble amyloid-beta levels and a 75% reduction in amyloid-beta plaques ! More to come.....
( Science 2012 Feb 9 )

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