Researchers in a study of 75,708 participants found that low levels of APOE in the blood reflects a low level of APOE in the brain which indicates that Beta-amyloid is less effectively removed. Beta-amyloid in excess is toxic to brain cells.
Low plasma levels of APOE are associated with increased risk of future Alzheimer's and all causes of dementia.
Plasma levels of APOE may be a new preclinical biomarker.
Annals of Neurology Feb 2015