Xeomin (incobotulinumtoxinA) for the treatment of chronic sialorrhea in adults (ages 20-80) such as that seen in Parkinson's disease. Also those adults with cerebral palsy, MSA, PSP.
100 units is injected into 4 sites in submandibular glands bilaterally.
NB! Exclusionary criteria: patients on coumadin, + history of Myesthenia Gravis, Lambert-Eaton syndrome, ongoing substance abuse, cognitive impairment < 23/30 on Mini Mental Status exam.
I use atropine opthalmic drops under the tongue with great success in select patients in my practice.
ClinicalTrials.gov ID : NCTO1653132