Zecuity ( sumatriptan iontophoretic transdermal system ) has been FDA approved for treatment of migraine.
53% of patients treated were headache free and 84% nausea free at two hours.
Zecuity is manufactured in Conshohocken,PA by NU Pathe
Sunday, March 24, 2013
Hearing Loss is Associated With Accelerated Cognitive Decline
Cognitive testing was performed on 1,984 older adults at five, eight, ten and eleven years. A total of 1,162 individuals with baseline hearing loss had 41% and 32% greater scores on 3MS and Digit Symbol substitution Tests respectively compared to those with normal hearing.
The conclusion, those with hearing loss had a 24% increased risk for cognitive impairment.
JAMA online Jan 21, 2013
The conclusion, those with hearing loss had a 24% increased risk for cognitive impairment.
JAMA online Jan 21, 2013
Lightning Triggers Migraine
In this study, ninety patients with headache underwent a review of their headache diaries over a 3 to 6 month period. The results indicated that there was an increased likelihood of having a headache on days with lightning after other variables associated with thunderstorms were added as covariates.
The mechanism resulting in this phenomena is unknown.
Cephalgia Jan 24,2013
The mechanism resulting in this phenomena is unknown.
Cephalgia Jan 24,2013
Alzheimer's Disease Short Course Treatment
This is a follow-up to a previous blog entry related to IVIG treatment of patients with Alzheimer's disease from the Mayo Clinic, Rochester,MN.
Patients with early Alzheimer's disease receiving five doses of intravenous immunoglobulin (IVIG) over an eight week period showed significantly less brain atrophy after 1 year than a placebo group.
The problem is that IVIG is derived from human donor plasma and is extremely scarce supply. It's primary neurologic application to date has been in the treatment of patients with Guillain-Baré syndrome. Production capabilities for all current suppliers could not begin to provide enough for all patients with mild to moderate Alzheimer's disease, let alone the even larger population with mild cognitive impairment.
Therefore, if a short-term dosing regimen is as effective as continuing therapy, it would extend current supplies that may be provided to a larger number of patients.
Kile S, et al "Initial findings of a randomized double-blinded placebo-controlled study of intravenous immunoglobulin in mild cognitive impairment due to Alzheimer disease" AAN 2013; Abstract P01.013.
Patients with early Alzheimer's disease receiving five doses of intravenous immunoglobulin (IVIG) over an eight week period showed significantly less brain atrophy after 1 year than a placebo group.
The problem is that IVIG is derived from human donor plasma and is extremely scarce supply. It's primary neurologic application to date has been in the treatment of patients with Guillain-Baré syndrome. Production capabilities for all current suppliers could not begin to provide enough for all patients with mild to moderate Alzheimer's disease, let alone the even larger population with mild cognitive impairment.
Therefore, if a short-term dosing regimen is as effective as continuing therapy, it would extend current supplies that may be provided to a larger number of patients.
Kile S, et al "Initial findings of a randomized double-blinded placebo-controlled study of intravenous immunoglobulin in mild cognitive impairment due to Alzheimer disease" AAN 2013; Abstract P01.013.
Sunday, November 25, 2012
Daytona Casual Test- Lotus Exige S Honda Powered
Driver : Christopher Prusinski
Engineer : Steve Mason
Event : PBOC Daytona October 2012
Saturday, November 24, 2012
Uncontrolled Hypertension Treated with Renal Denervation
Renal denervation, an intravascular procedure that employs radiofrequency pulses induces denervation of the sympathetic innervation of a patient's renal arteries. Approximately 10,000 patients have been treated worldwide resulting in a drop in blood pressure of 28/10 mm Hg in patients that began their treatment with pressures of approximately 180/100 mm Hg, with a response rate of over 90% and a duration of over 36 months of follow-up.
Additionally, RD was applied to normotensive patients with heart failure resulting in a 25% improvement in left ventricular ejection fraction 12 months after RD.
RD is investigational in the US.
Annual Congress of the European Society of Cardiology (Munich)
Additionally, RD was applied to normotensive patients with heart failure resulting in a 25% improvement in left ventricular ejection fraction 12 months after RD.
RD is investigational in the US.
Annual Congress of the European Society of Cardiology (Munich)
Intranasal Stem cell Delivery in PD Rat model
Mesenchymal stem cells (MSC) were delivered into the nose preferentially migrated to the brain and survived up to six months improving motor function significantly (up 68%) in the rat model of Parkinson's disease. Levels of dopamine were much higher in the treated rats.
Rejuvenation Research Volume: 14 Issue 1: February 17, 2011
Rejuvenation Research Volume: 14 Issue 1: February 17, 2011
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