Fatigue In MS

   Fatigue is an overwhelming sense of tiredness and is often considered the leading symptom in multiple sclerosis.     Significant fatigue in isolation may precede a diagnosis by several years (Mult Scler 2013;19(11):1526-1532)
  Fatigue at the time of a first attack of MS (CIS) independently predicts a diagnosis of MS (J Neurol Neurosurg Psychiaty 2015;86(5):543-546)