From the Harvard aging brain study, greater amyloid deposits in brain were seen in individuals with LOW BMI (thin folks). However, those that were APOE4 carriers (increased risk with each APOE4 mutation you carry), NORMAL BMI (normal weight) was associated with greater amyloid burden in brains.
Amyloid at high levels is toxic to our brains.
Journal of Alzheimer's Disease June 18 2016
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