Impaired Glymphatic System After Brain Injury ?

  Glymphatic system function was reduced by 60% following traumatic brain injury in experimentally modified mice for at least one month. 
  In mice genetically modified to lack aquaporin channels (crucial in facilitating spinal fluid transport from the periarterial space to the interstitial space to drive waste removal via the glymphatic system) that sustained brain injury, the glymphatic system dysfunction was further exacerbated causing neurodegeneration and neurofibrillary pathology like that seen in the brains of humans with chronic traumatic encephalopathy.
  These findings have potential to enhance our understanding of the changes that take place in brain injury with further efforts needed to lessen the impact of such.
J Neurosci.2014;34(49):16180-16193